If you're doing hit-and-run and utilizing your rumours properly you shouldn't be in this situation in the first place, you incompetent. (Seriously, though? Depends on a lot of factors. How horrible is the relationship? How difficult it is to get the relationships back up to green again? How useful/essential to success is the person in question? Is it just two people who hate each other? Can you feasibly separate your survivors into two groups, so your relationships go back to a neutral place again? How bloodthirsty are you feeling today? Etc.) EDIT: If you DO kill somebody off though, make sure to milk them for all they're worth. Suicide breaches are always fun, for example.